Workshop: Holistic Oncology, short

After introductory remarks, the Workshop presenter will examine the weaknesses and strengths of the Conventional and Integrative oncology systems. Thereafter, we will compare the strengths and weaknesses of Holistic Oncology, focusing on the Institute’s anti-cancer  mini-protocols. Hereinafter, the topics that will be covered. This workshop will be presented via powerpoint.

Content

1. Evaluating the molecular biology of the tumor cell population and, in particular, its CTC and CSC spreads. (CTC – Circulating tumor cells & CSC – cancer stem cells) as well as other tests.  We will look at some of the best labs where the patient-student can order most tests directly. We will also delve into exegesis, or how to interpret a few of these cancer tests and what to aim for. Reviewing efficient and safe monitoring techniques to make sure the chosen options are consistent with evidenced-based progress in cancer control and reversal.

2. Carcinogenesis and the major Cancer Hallmarks: Is cancer a genetic, epigenetic, infectious, immune, neurological or metabolic disease ? (1)

3.  Examining the conventional and holistic cancer diagnosis.

4. Studying the strengths and limitations of conventional allopathic oncology. (2) Case studies.

5. Strengths and weakness of integrative oncology. Case studies.

6. Introduction to Holistic Oncology: Definition and general principles. On the issues of Evidence, standards of care and Randomized Clinical Trials. (3) Case studies.

7. Holistic Detoxification (metabolic and exogenous).

8. Chosing an adapted diet that corresponds to the patient’s health challenges, terrain and genetic constitution. Ph regulation. Stress management, heat therapy and exercises. Dealing with the glycolysis and specific anti-cancer clinical nutrition, spices and herbs. 

9. Turning off the pathways that govern excessive free radicals and growth factors which promote cancer development.

10. De-activating malignant angiogenesis.

11. Quieting the malignancy-based inflammation cascade.

13. Correcting coagulation.

14. Immune-building, immune-modulation, re-activation of the innate immunity and the dendritic surveillance system.

15. Addressing key genes (downregulating oncogenes and upregulating tumor suppressor genes).

16. Dealing with cancer stem cells, the inhibition of micro-metastases and metastasis pathways.

17. Reviewing other anti-mitotic, metabolic and anti-cancer proliferation holistic techniques, from hyperthermia to electric regulation, acupuncture and electro-acupuncture, to oxygenation improvement, cellular homeostasis, atp normalization and selective malignant cyto-toxic natural substances that induce apoptosis and malignancy necrosis, among other activations.

18. Exploring fasting techniques: From alternate fasting, to intermittent fasting, water fasts, juice fasts and the fasting mimicking diet. Exploring autophagy, circadian rhythms, Telomeres, hormonal and stem cell regeneration.

19. Essential Oils, lymphatic massage, EFT,  Meditation techniques, sleep, exercises and other anti-stress techniques.

20. Maintaining bone integrity, managing cancer pain and oxygen therapies: from the HBOT (hyperbaric oxygen chamber), to the floating chamber, to the altitude chamber, to aromatherapy, the Bol de Jacquier technique, breathing exercises and more.

21. Repairing and-or correcting allopathic oncology’s damages (when possible, from cancer wounds that don’t heal well, to traumatizing surgeries, to radiation fibrosis, to chemo brain fog, to immune and gut destruction and allopathic cancer stem cell activation).

22. Nurturing emotional wellbeing and spiritual health.

23. Dentistry and energy medicine.

24. Addressing cancer via the cellular senescence and longevity pathways. 

23. Supplementation

24. Addressing cachexia, anorexia, pain and social-family issues.

25. Medical law: Rights of patients, duties of doctors and obligations of public entities that deal with public health.

1. The Detoxification Protocol

Activating  detoxification pathways (metabolic and extrinsic).

Both metabolic and holistic detoxification are fundamental and unifying tools in holistic medicine. In the same way  that Traditional Chinese medicine starts with dispersing (and not tonifying) acupuncture point, in a similar way, holistic healing  must first start with the “less is more” strategy, with the lowering of the  body’s toxicity load, if only because we want to both clean-up endocrine, metabolic and immune signaling pathways and promote the healing crisis mechanism, the one Conventional medicine’s dignitaries choose not to teach.

“Chemicals that store in lipid-rich compartments have the potential for long-term disruption of metabolic and endocrine processes. Given the evidence that persistent organic pollutants (POPs) also alter systemic metabolic, endocrine, and immune system functions, it follows that elevated chemical concentrations in intra-abdominal fat may alter function, through local chemical signaling, of visceral organs.” (Source)

2. The Microbiota-Enhancing Hydration & Nutrition Protocol

Once the major emonctory and drainage organs have completed their detox task, the HIT protocol recommends one of three types of diets adapted to the patient’s genome, constitution, microbiota and health challenges, in this case, the type of cancer, its virulence, spread and nature. Although each of these anti-cancer diets works on common pathways, including, but not limited to the strengthening of the immune-surveillance system and the targeting of  glycolysis, angiogenesis & other cancer pathways, each of them has biochemical specificities, the modulation of which is bilaterally determined by both the patient’s conditions and tastes as well as by the nutritionist counselor. (11) Food-medecine is usually not enough to  reverse cancer, but it’s an important part of the Institute’s cancer control and reversal strategy and all the more so that food determines the diversity and nature of the microbiota. Bacteria genes cross talk with the human’s genome and the immune system. By not addressing this variable, conventional oncology’s immunotherapies will not be very long term efficient.

3. Psycho-neuro-endocrinology, Meditation & Attitude Protocol

Once the body and its microbiota have been been cleansed, remineralized and correctly nourished, the third protocol focuses on stress management and brain-wave regulation. Nurturing emotional wellbeing and spiritual health is too often neglected in the mainstream, hence the poor results in conventional oncology. The evidence that confirms this claim is overwhelming. In this field, the Institute’s team teaches multiple psycho-neuro and neuro-science techniques, from different forms of meditation, to sophrology, visualization, breathing, acu-pressure and tapping, trauma therapy, musicotherapy and mindfulness, the effectiveness of which has been corroborated by many published studies.

Furthermore, an abundance of studies shows that “patient passivity” is often disempowering and lethal. There is evidence that shows that cancer patients tend to be too “nice”, too “forgiving”, too “passive”, not emotionally “inflammatory” or “angry” enough against medical incompetence, frustration and bad stuff.  As a consequence, their immune & microbiota systems dont work as well as those patients who cultivate righteous “anger”. Contrarily to this “saintly nice forgiving at all times anti-cancer personality” that some alternative cancer marketers broadcast, the evidence shows that without being righteously “angry”, it’s difficult to be proactive. Fear-based emotions tend to become stagnant, that which blocks the energy flow, general homeostasis and restoration. Righteous anger is not hatred, it is a releasing of stagnation, of pent -up energy that inhibits “chi”, energy flow, the immune system. For the immune system, the “inhibition of action” is quite deleterious. French Professor Laborit eloquently demonstrated this decades ago. By firmly questioning doctors’ belief systems, dogmas, injustices, corruption and incompetence, intuition, survival instincts and pro-activeness are able to express themselves.

4. Caloric Restriction, Intermittent Fasting and the FMD

Caloric Restrictions , CR mimetics, time restrictive eating (Intermittent Fasting), therapeutic water fasts and the fasting mimicking diet can all favorably modulate cancer control and reversal.  But there are many different conditions that need to be met before this millenia medicine can be put in place. And any kind of dietary deprivation should be done under the care of a Fasting expert. For over one hundred years, a large body of medical evidence shows that restricting calories at least 30-50% below average efficiently inhibits aging processes in all species tested. Different molecules like resveratrol and metformin can act as mimitics, but supplements are unsatisfying for the human spirit and Holistic Oncology. When possible, we prefer mixing fasting and-or caloric restriction with the right supernutrients that are all the more needed if the body’s is to clear cancer cells without over-burdening the kidneys and the vasculature.

 5. The Inflammation Modulation Protocol

Reducing and modulating the fire of excessive free radicals, cytokines and other inflammatory processes are all permament fixtures of the HIP protocol. This general backdrop is important because one of the key drivers of both the aging process and the malignancy process is chronic inflammation. Just like with quality wine, a little inflammation is needed to kick-start the immune and microbiota system’s into holistic action, but too much systemic inflammation (like too much wine) harms. Dosage is key. Likewise with the anger emotion.  A little “righteous” acute anger can be beneficial, while chronic anger is cortisol-producing, acid-forming and destructive. (See section above Nu 3). This is one reason we generally prefer to speak about modulating inflammation rather than focusing on anti-inflammatory procedures and substances.

6.  Anti Growth Factors and Angio-genesis Protocol

Cancer’s goal being the total invasion of the host, the malignancy process activates and-or promotes many growth factors, from IGF-1 and mTOR, to VGF, EGFR, FVGT and many other growth pathways, all of which are inter-connected. Up to 2 millimeters, a tumor can not survive without the activation of angiogenesis, one of the key growth factors. Over 2 millimeters, in general (there can be exceptions),  the vascular angiogenesis system supplies cancer cells with the vessels that are needed for maximum nutrients and oxgyen intake. Contrarily to what many oncologists believe, especially integrative oncologists, cancer cells do require oxygen. This is one of the disputes Professor Seyfried has with Professor Weinberg. Yes,  cancer cells use aenarobic fermentation like primitive cells millions of years ago. But these immortal cells also uses aerobic respiration. (See mechanisms). It is therefore imperative to timely address this hallmark of the cancer process.  The Institute does this holistically.

7.  Anti Glycolithic Pathway Protocol

Cancer thrives on multiple mechanisms, including, but not limited to the glucose and glutamate pathways. Whatever spikes insulin, boosts IGF-1, a molecule that cancer cells need.  Food and supplements can have an impact on this front. Cancer cells are metabolically flexible. Contrary to what Dr Mercola and other keto-paleo advocates  teach, cancer cells also thrive on lipids (especially animal cholesterol) and amino acids.   In this perspective, the ACR Institute recommends Holistic Techniques that target autophagy and, inter alia,  cellular respiration. (Inter alia is legal latin for “among other elements”).

 8. Holistic Anti-coagulation Protocol

Cancer patients are at a higher risk than the general population of developing serious blood clots, including but not limited to deep vein thrombosis (DVT) in the legs or pulmonary emboli in the lungs. There is a balance in the body between pro-clotting and anti-clotting activity, but cancer cells skew the balance in terms of pro-clotting, increases inflammation, and compresses blood vessels, all risk factors for developing clots. Treatment for cancer or blood disorders can also affect the balance of pro- and anti-clotting factors, and increased bed rest during treatment may enhance a patient’s risk of clotting. Furthermore, one of cancer’s characteristics is to thicken the blood so that its seeds (via the micro-metastasis pathway) can better adhere and embed within distant tissues, including galectin-3. To this end, the cancer process alters the coagulation cascade as well as the cell’s sodium-potassium pump and dispatches “adhesion” molecules to better colonize distant tissues. In addition to the promotion of metastasis and inflamation, this process also produces clot formation, from which many cancer patients die. It is therefore necessary to correctly address this aspect of the cancer process, if only because too many cancer patients die from thrombosis and pulmonary emboli way before the cachexia phase of the disease.

Workshop on Hormonal and neurotransmitter boosting and balancing as tools to develop more "joie de vivre" (enjoyment of Life). Click picture for details.

Top: red hot peppers, a great way to boost endorphins, immune function and metabolic pathways. Image licensed under cc.

 9.  The Institute’s Immuno-modulation Protocol

The fixing and boosting of the patient’s immune system is paramount.  First, the innate immunity system, then the adapative one. The dendritic surveillance system also needs to be find-tuned as well as the microbiota, the gastro-digestive system and the central automatic nervous system. The ACR Institute proposes a unique approach that helps to block immune check-points, CD 47 and other receptors and proteins that hinder cytotoxic T and NK cells from the clearing of cancer cells. (11 c)

Moreover, by  restoring the immune surveillance system, the immune system will store the memory of the malignancy. This is a quasi-guarantee against the recurrence of that type of cancer. This also means that if a circulatory tumor and-or cancer stem cell starts to colonize new tissues, the immune surveillance system will send an alert signal to the cyto-toxic T cells, which will move forward to remove cancer cells. In the mainstream, there are multiple experimentations and clinical trials with immunotherapeutics, from checkpoint inhibitors to the expensive T-Car approach, monoclonal antibodies, vaccines and more. But most of these techniques have serious side effects (including autoimmunity) and cancer cells tend to outsmart them and later on, come back.  There are couple mainstream immunotherapeutic techniques that show promise, but it is too soon to ascertain their long term effects. Hence, the ACR Institute prefers its holistic approach, which appears to activate not only apoptosis, but also cell differentiation and necroptosis. (11 d) More clinical experimentation is still needed to fine-tune this approach, but so far, anecdotal evidence, experimentation and basic science suggest that this approach is the safest, the most effective and the least costly.

10. Genomic Stability Protocol: DNA Repair

Cancer genes are relevant and should be addressed. But not as a priority since the genetic process of cancer is downstream to more significant metabolic processes. In this perspective, the upregulating of anti-tumor genes like the P-53 or P-21 (both of which modulate apoptosis, inter alia) and the downregulating (dormancy process) of tumor genes (oncogenes) like the RAS genes are as important as the targeting of repair and longevity genes insofar as cancer control and reversal are concerned.

In terms of  DNA repair,  thanks to innovative and holistic DNA repair activation and to DNA repair enzymes, the discovery of which was recognized by a 2015 Nobel Prize in Chemistry,  the body’s cells, both healthy and cancer cells, are able to repair defective DNA and alter signaling pathways. The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. With time, a cell  accumulates a large amount of DNA damage, and can  no longer effectively repair damage incurred to its DNA. As a consequence, it can enter one of three possible states: (a)  an irreversible state of  inflammatory dormancy, known as senescence  (b) cell suicide, also known as apoptosis or programmed cell death (c) unregulated cell division, which can lead to the formation of a tumor that is cancerous. The DNA repair ability of a cell is vital to the integrity of its genome and thus to the normal functionality of that organism. In this mini protocol, we will examine key repair genes. We will also examine innovative and holistic techniques that can enhance DNA repair mechanisms of the good cells while reducing oxidative stress, from the best sleeping, nutritional and lifestyle techniques to the right combination of  micro-nutrients and zinc. With regard to certain cancers,  we will show how holistic savoir-faire can favorably impact over 500 cancer and cancer-suppressor genes.

11. The Transcriptome, Epigenesis, Peptides and Exosomes

The contributions of mRNA sequencing and Epigenetic science have been eye-opening insofar as cancer and longevity are concerned. New discoveries with different peptides and exosomes have also contribued in the determination of a credible  cancer-free rejuvenation program. In this mini-protocol, we will examine what cancer and senescent clearing techniques can be activated from the confort of one’s home.

Stem cell driver

Top, the cancer stem cell driver, a too often forgotten “actor”  in the malignancy process

12. Cancer Stem Cells  and Healthy Stem Cells Protocol

Cancer stem cells have been shown to be one of the central engines  of metastasis as well as one of the best prognosis tools we have. It is therefore imperative to both target and monitor the circulatory tumor and stem cells that are in the bloodstream. While there are presently RCT (clinical trials) on diffferent conventional drugs to obliterate these cancer stem cells, it will take many more years before they are brought to the market. Furthermore, they may be laden with serious side effects. However, holistic oncology already has non-drug tools to remove CSCs (cancer stem cells) from the body.

On the other hand, non cancerous stem cells are quite beneficial for the entire body, including when systemic cancer strikes.  Embryonic stem cells (ESCs) are the cells of the inner cell mass of a blastocyst, formed prior to implantation in the uterus. In human embryonic development the blastocyst stage is reached 4–5 days after fertilization, at which time it consists of 50–150 cells. ESCs are pluripotent and give rise during development to all derivatives of the three germ layers: ectoderm, endoderm and mesoderm. In other words, they can develop into each of the more than 200 cell types of the adult body when given sufficient and necessary stimulation for a specific cell type.  As age accumulates, the body tends to deplete these Master molecules, that which hinders tissue repair. From prolotherapy to tissue regeneration, stem cell differentiation and activation have significantly impacted optimal longevity and cancer control-reversal.

13. Mitochondrial, hormonal and neurotransmitter biogenesis and restoration

New discoveries in cellular respiration, endocrinology, nutrition and neuro-science help us to understand not only how to prevent chronic diseases, but also how to successfully treat them, including, but not limited to Alzheimer’s Disease, Hashimoto, CVD, cancer and diabetes.  Concomitantly, emotional strain and chronic stress are also significant aging and carcinogenic factors that need to be addressed. In this mini protocol we will also show how to monitor and rebalance one’s blood sugar levels and keep one’s insulin receptors as sharp as a merdeces’ spark plugs. Optimizing one’s mitochondria, lipid profile, thyroid function and revitalizing one’s sexual hormones and neurotransmitters are also important for both longevity optimization and cancer reversal.

14. Micro-metastases Protocol

This protocol looks into  anti-mitotic substances as well as  anti-cancer proliferation techniques, from electric regulation, electro-acupuncture, to oxygenation improvement, cellular homeostasis, atp normalization and selective malignant cyto-toxic natural substances that remove metastastic cells while inducing apoptosis among those cancer cells that have been resensitized to this mechanism.

15. Glycoprotein (P-gp) Efflux Pumps Holistically addressed

Transmembrane efflux pumps are expressed by healthy as well as cancer cells and act to clear the cells of toxins. Some cancers ramp up expression of pumps called P-gp, (glycoprotein) and another pump known as breast cancer resistance protein (BCRP), in response to anticancer drug therapy. To avoid getting killed, cancer cells  use this built-in defense system and other pathways, including other cells and molecules they recruit. Although the HIP protocol does not use chemotherapeutic agents, some of its proposed supplements, herbs and phytonutrients can have cytotoxic effects cancer cells dislike.  As a consequence, cancer cells’ pumps such as P-gp and BCRP may be all the more expressed. Conventional oncology research has had limited success in blocking the overexpressed P-gp cancer transmembrane pumps. None reached the cancer industry’s market given the toxicity of these synthetic P-gp inhibitors. (Source). (11 e)  Cumulative evidence suggests that it is the Cancer Stem Cells (CSCs) that are responsible for this detoxification pumping, how could they not, being the tumor’s central architects. (Source).  Because the ACR Institute’s HIP protocol is successful with regard to the clearing of CSCs, we can infer that this may be in part because the HIP’s herbs (phytonutrients and or phytochemical) sneak into the CSCs without activating the cancer “beast’s” transmembrane pumps. We do have evidence of this  P-gp inhibition from the herbs we propose in the HIP’s protocol. (11 f) This mini-protocol is a back-up tactic in case the immunotherapy and other components of the HIP protocol are not sufficient.

16.  Physiotherapy, Heliotherapy and Electrotherapy Energy Enhancement Protocol

The evidence shows that those who exercise moderately fare better than the cancer patients who don’t. Movement is Life. To energy and immune boosting exercise, can be added massage, lymph activation, spinal adjustment, sacral cranium work, acupuncture, pmef, frequency modalities among other techniques. Brittle bones are often a consequence of both cancer treatment and the malignancy process. The patient needs therefore to strengthen the bones and all the more so that cancer in the bones is a painful process.

17. Oxidative Protocol

Oxygen is a key player in the recovery process. The HIT protocol investigates different modalities of oxygen intake, from the HBOT (hyperbaric oxygen chamber), to ozone therapy, Vitamin C IV therapy (in large dosages, vitamin C acts like a pro-oxidant), the floating chamber, the altitude chamber, to aromatherapy, the Bol de Jacquier technique, breathing exercises and more.

18. Cancer Pain Management Protocol

Inflammation and lack of oxygen via tumor blockages create pain. It is therefore useful to know what integrative and holistic techniques exist to control and reverse pain without depressing the immune system or affecting nefariously other bodily functions.

19.  Cachexia & Sarcopenia  Protocol

As for sarcopenia and cachexia (muscle-wasting), these processes are end-stage cancer hallmarks that can often be better controlled with holistic oncology than conventional medicine. And depending on the patient, prior treatments and the evolution of the disease, cachexia can be reversed.

20. Tumor Lysis Protocol

Tumor Lysis (also called cancer “die-off”) is important because if there are too many necrotic cancer cells in the bloodstream, the kidneys  and immune system can get overwhelmed.

21. Supplementation Protocol

Depending on the cancer and the patient, different supplements, neutraceuticals, mushrooms and herbs can be indicated. In this protocol, we examine which are the most useful and scientifically grounded, in particular for which type of patient and cancers. Genomic individualized testing may also be needed in order to first know how the patient’s genes and proteins will react to a given supplement or molecule.

22. Integrative and-or Conventional Adjunctive Protocol

When needed and depending on the patient’s belief system, integrative or conventional techniques can be envisioned. But as adjunctive interventions, this way we first allow the body to holistically restore its healing and cancer defense mechanisms. To first apply conventional techniques as a major protocol is absurb giving it’s damaing and reoccurance effects, including on the immune and microbiota systems.  In this field,  low dose cytotoxic chemo and radiation (i.e., chemo-radiation) can be associated to hyperthermia, intermittent and-or caloric restriction, prolonged fasting, antioxidants, autophagy modulators and, among other techniques, insulin potentiation therapy (IPT). Allopathic oncology’s cancer drugs can also be safer and more effective in combination, either with other drugs targeting complementary pathways or with neutraceuticals (supplements) and foods.  Low dose Naltrexone, Alpha Lipoic Acid, Vitamin C & K,  DCA, genestein, poly-mva, laetrile, cannabinoids, anti-fungals, and many other molecules like metformin can be envisioned in the integrative oncology perspective if the patient so desires.  (12) Likewise with genetic and transcriptomic interventions (12 b)

PUT nutrition workshop

Essential Oils

Wine ??

Workshop Instructor: Pr. Joubert. Biogerontologist and Holistic Oncology Expert. Director of the ACR Institute

Immune-modulation and holistic oncology workshop

“The overall contribution of curative and adjuvant cytotoxic chemotherapy to 5-year survival in adults was estimated to be 2.3% in Australia and 2.1% in the USA”. Cf. Morgan G1, Ward R, Barton, The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. M.  Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.    (Source

References

(1). For M.I.T.’s Professor Weinberg and most of the other recognized mainstrain allopathic oncologists, cancer is a genetic disease with six inter-related cell physiology alterations: 1) autonomy in growth signals, 2) insensitivity to growth inhibitory (antigrowth) signals (e.g. tumor suppressor genes), 3) evasion of programmed cell death (apoptosis), 4) limitless replicative potential as long as there’s glucose in the micro-environment, 5) sustained vascularity (angiogenesis), and 6) tissue invasion and metastasis. (Source) . While we do not refute the importance of these above-mentioned elements, the Advanced Cancer Research Institute’s fundamental research work has determined that these above mentioned cancer hallmarks are “epi-phenomema”, meaning not central to the cancer process, if only because it has been shown that a damaged mitochondria prevails over an altered nucleus insofar as malignancy is concerned. (Source) In order to benefit from cancer reversal, the health recipient must activate a treatment plan based on a correct analysis of carcinogenesis. This is the starting point to any and all safe and efficient cancer control and reversal processes.

(2). To whet the student’s appetite, a few facts: For most of the  common solid cancers, mainstream conventional cancer treatments based on cyto-toxic chemo-therapy bestow upon cancer patients less than  3 percent “five years” survivability success rate. (See quote above) Not only can chemotherapy worsen the tumor’s micro-environment, it can also make the engins of metastases, the cancer circulating stem cells, mutate and spread even more.  Radiation has a similar effects. (Source)  Likewise with many biopsies and surgeries, they too can significantly contribute to the spreading of  the malignancy, via the cellular adhesion, immune suppression, surgical stress and inflammatory pathways. And to make matters worse, many conventional diagnoses and prognoses have built-in and often  fatal flaws.

(3). Given the costs of Randomized Clinical Trials (hundreds of millions to billions of dollars), human RCT  can’t exist in holistic oncology, if only because most of holistic oncology is lifestyle medicine and this type of medicine is not patentable, nor can it be squeezed into a double blind RCT, if only because the patient is aware of the holistic technique in question.  On the other hand, there are  prospective, epidemiological, observational and interventional studies that confirm holistic and integrative oncology’s clinical superiority over conventional oncololgy, some of we will review in this workshop.

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