- 1 Lesson 17: Holistic Nutrition, Gastroenterology, Weight Management & Diabetes.
- 2 Lesson 18: Dietary Supplementation & Optimal Longevity
- 3 Lesson 19: Chronic Stress, Accelerated Aging, Placebo-Nocebo & The Inner Saboteur
- 4 Lesson 20: Inflammation, Auto-immunity and Infections
- 5 Lesson 21: Cancer Hallmarks
- 6 Lesson 22: Advanced Holistic Malignancy Control and Reversal Protocols
- 7 Lesson 23: Heat Medicine: A French & German Speciality that would be of Benefit for the US Health-Care system
- 8 Lesson 24: Optimizing balanced Hormones & Neuro-transmitters & Regulating Cytokines
- 9 Lesson 25: Activating & Tweaking Key Longevity Genes
- 10 Lesson 26: Mitochondrial Bio-Genesis’ Restoration: From Cancer and Longevity to Fasting and Mitochondrial enhancers
- 11 Lesson 27: Stem Cells: Repair, Replacement & Regeneration
- 12 Lesson 28: Telomerase Therapy
- 13 Lesson 29: Cellular Senescence, Autophagy, Regulation & Amyloidosis
- 14 Lesson 30: Circadian Rythms Activation & DNA Repair
- 15 Lesson 31: Monitoring Tests: From Self-testing to Genetic, Gut, Telomere & Methylation Evaluation
- 16 Lesson 32: Today’s Bio-Engineering of anti-aging pharmaceuticals & Hi-Tech procedures
- 17 Lesson 33. Conventional Cancer Research and Innovations
- 18 Lesson 34: Summary & Conclusion
Lesson 17: Holistic Nutrition, Gastroenterology, Weight Management & Diabetes.
“He will not look upon the rivers, the streams flowing with honey and curds”. Job 20:17
The Internet, bookstores and libraries are replete with nutritional claims that are often contradictory and scientifically spinned or biased, including, but not limited to dash-paleo-keto high-fat, mid-animal proteins, low-carb, high-calorie schools diets which tend to be inflammatory and deleterious for long term health and longervity. On the other hand, anti-inflammatory plant-based, high fiber, high bitters, mid vegan fats, low protein, low calorie and high low-glycemic carbs ancestral diets tend to avoid chronic diseases and optimize longevity, including the mostly plant-based Mediteranean diet, as long as this diet has a low amount of clean quality animal foods, including raw organic honey and wild small clean fish (ie, Smash). But diets that include more than 5 percent animal foods (depending on the person’s gene pool) and-or have loads of processed foods tend to be deleteriously inflammatory and, inter alia, toxic to human kidneys, the endothelium and overall health. In other words, as Michael Polene put it, the available evidence suggests that Evolutionary Biology formed humans to be “mostly plant-based” eating fresh, whole and clean foods.
The Holistic Mediterranean Diet is an improvement over the classical Med-Diet in that it upregulates and improves the expression of thousands of genes while diversifying the microbiota like no drug or other diet can. For many decades, the prevailing evidence had determined that the classical South European Mediterranean Diet has been the best human longevity diet. Thousands of published papers in the best peer-reviewed journals corroborate this piece of allegation. Even the controversial Ancel Keys ended up adopting the Med Diet by moving to South Europe where he lived with his wife in decent shape until he reached 100 years. (Source) The French version of this classical Italo-Greek Diet is what super-longevity champion Jeanne Calment thrived on until 122 and a half years. Out of over a dozen Mediterranean versions of the Med-Diet, the ACR Institute’s Holistic Medicterranean Diet has fine-tuned this nutritional regime by taken the best of all of these Med-diet versions, from the Med-diet of Kosher Israel, to the mint-humus Med-diet of Morocco, Lebanon, Spain, Turkey, Icaria, Italy, Corsica, Croatia, Slovenia and more while improving it in light of new scientific discoveries, daring medical hypotheses and intuitive guidance. The tentative conclusions are as follows: When done properly, the best diet in general for human longevity is the vegan diet without supplementation. But because this diet may be difficult to apply, the second best is the vegan diet with supplementation. And the third best, the advanced Mediterranean diet.
In this Lesson, we will examine the compelling evidence that proves which diet is the best for which group of people. For example, some people have genetic variations that keep them from properly digesting garlic or broccoli while others have allergies and-or intolerances to soy, gluten, nuts, fish and dairy. As a result, nutrition needs to be tailored to a person’s SNPs and needs.
What is the Best Diet for Energy Production, Memory Maintenance, Hormonal Optimization, Tissue & DNA repair, immune-enhancement, blood & Lymph circulation, stem cell regeneration, the immune system and Cancer-Free Long Lifespans to 120 Years that is also good for the Planet ?
The “Paleo-Keto-Mediterranean-Vegan-Caloric Restriction-Diets” Debate
An effective recipe to die crippled with an onslaught of chronic diseases : Case Studies on the SAD-MAD (standard or modern American diet), Keto,Paleo & Carnivore Diets
The Doctrine of Signatures (Teleological Nutritional Targeting)
Holistic Solutions to Low Stomach Acid
Holistic Solutions to Slow Bowel Movement and constipation
Holistic Solutions to Food Allergies
Case Study on how simple and cost-effective it is to reversing Diabetes Holistically
Case Study: Soy & Health
Case Study: Can Quality A2 Traditional-made Cheese be a Longevity and Medical Food ?
On the delicate issue of Yogurt and Cheese: No question, dairy has it’s inconveniences and there is usually no human physiological need to indulge in dairy, except mother’s milk, a third of which is insoluble fiber. But fermented A2 yogurt and cheese from humanely & lovingly raised goats and sheep has been shown to be indicated insofar as the activation of the longevity pathways are concerned. In France, cheese is prefered raw and organic, from grass fed animals, without antibiotics and artificial hormones and combined with wine. Although A-1 cow cheese is cheaper, most of the French prefer A-2 sheep and goats cheese, if only because these cheese have healthier casein protein and lipid profile than cow cheese, hence the gusto-olfactory contentment. As an accompaniment, polyphenol-rich wine and when available, organic fresh grapes, olives and nuts are also indicated. This custom helps with digestion, bio-availability, mineral balance, cholesterol reduction and estrogen elimination. Organic catechin-rich Green tea can also help to burn cheese’s rich saturated and unsaturated fat content while flooding the bloodstream with complementary antioxidants, blood-thinning compounds and immuno-building molecules. A2 cheese is also rich in important fats, like DHA as well as its many fat-soluble vitamines, like Vitamin A, D and the prized K-2 and B-12 etc.. For certain chronic diseases like Diabetes 1, M.S., R.A. progressive arthritis, infections, autoimmunity and Advanced Prostate cancer, all dairy should be avoided. But for healthy people who wish to attain the supercentenarian level, the up-to-now objective evidence shows that quality A-2 cheese in moderation or in small amounts from time to time and from humanely-care animals can both favorably diversify the microbiota and boost longevity and anti-cancer pathways. Yes, just like Flemming’s penecillin molds zap deleterious bacteria, recent published findings have confirmed key molecules in certain moldy cheese that can zap cancer cells. Raw organic A2 traditionally made cheese that does not lead to animal cruelty would be the type of cheese to use. Vegan rennet would be even better. Yes, most times, the vegan diet is best. But under specific conditions, quality cheese can be a longevity and medical food, and all the more so that its probiotics, vitamins D & A nourish the immune system, making quality cheese non allergenic, at least for most eaters. And there is no need to mistreat animals to produce quality dairy. We will of course prove these claims with a preponderance of the hard evidence during the power point presentations.
The Institute’s Improved Mediterranean diet Rejuvenation Recommendations
Lesson 18: Dietary Supplementation & Optimal Longevity
“It’s not because we are old that we don’t play, it’s because we don’t play that we get old” (George Bernard Shaw)
Are non prescription pills, supplements and neutraceuticals useful or deleterious for durable health and optimal longevity ? Many conventional and integrative medicine, biogerontology and anti-aging specialists claim that many dietary supplements like niagen (nicotinamide riboside), resveratrol, D-ribose, vitamin D3, antioxydants, Fish and MCT-Krill DHA-rich Oils, Algae, Vitamin B-12, metformin, ketones, Co-Q-10, PQQ, berberine, L-Carnitine, NAC, BDNF boosters, vitamins D & K-2 and many other supplements are safe and efficient insofar as risk prevention and longevity activators are concerned. This talk will show the data that either substantiates some of these claims or debunks them.
For example, on one of dozens of supplements we may review, fish oils, the viewer can confirm via mouse click below the data that confirms that fish oils are less and less reliable as healthy sources of long chain Omega 3s, worse, not only the evidence debunked the claim that fish oils are cardio-protective, even if they may reduce tryglicerides, but they were shown via multiple published peer-reviewed meta-analyses to significantly increase cancer risks, including, but not limited to aggressive prostate cancer (ie with a 71 percent risk).
Are supplements needed to optimize Longevity ?
Are supplements needed to control and reverse cancer and other chronic diseases ?
Case Study A: Popular Supplementation for Healthy & Optimal Lifespans
Case Study B: Unsafe and-or inefficient Supplementation
Case study C: Examples of Dietary Supplements ending up as expensive urine
Case study D: A Published Study Claims a 20 percent increase of Liver Damage coming from Dietary Supplements
Case Study E: Resveratrol in a capsule, food or bottle ? Depends if one is a mouse, a patient, holistically inclined or a marketing agent
Case Study F: Analysis on Vitamin C, the big Electron Donor: Can there be disease-based exceptions with lyposomal Vitamin C, IV Vitamin C, ascorbate palmitate and sodium ascorbate ?
Lesson 19: Chronic Stress, Accelerated Aging, Placebo-Nocebo & The Inner Saboteur
“Here we provide evidence that psychological stress— both perceived stress and chronicity of stress—is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells from healthy premenopausal women. Women with the highest levels of perceived stress have telomeres shorter on average by the equivalent of at least one decade of additional aging compared to low stress women”. (Source)
Conventional Medicine has been ambivalent regarding the placebo effect in clinical practice. On the one hand, the placebo is disparaged as an inert and deceptive intervention intended to please or placate the patient but without any potential to produce meaningful therapeutic benefit. On the other hand, placebo effects are touted as having the power to produce substantial symptomatic relief across a wide range of medical conditions. During the past decade, there have been advances in scientific research on the placebo effect, paving the way for evidence-based techniques for promoting placebo responses in clinical practice in ethically appropriate ways. Additionally, practitioner surveys indicate that physicians today appear much more comfortable acknowledging the placebo effect as a therapeutic tool consistent with a scientific understanding of the mind-body connection. As for the opposite of placebo, Nocebo, Research has also shown its deleterious effects on both Longevity and aging.
Nocebo and Placebo Effects in Medicine
Successfully resolving the Self-Sabotage Disorder
Hands-on Techniques to enhance Longevity and de-activate the Inner Saboteur
Top: red hot peppers, a great way to boost endorphins, immune function and metabolic pathways.
Lesson 20: Inflammation, Auto-immunity and Infections
“Aging is the greatest risk factor for the development of chronic diseases such as arthritis, type 2 diabetes, cardiovascular disease, kidney disease, Alzheimer’s disease, macular degeneration, frailty, and certain forms of cancers. It is widely regarded that chronic inflammation may be a common link in all these age-related diseases” Immunol Rev. 2015 May;265(1):63-74. (Source)
As mammalian cells divide and transform into senescent cells, their communication with other cells becomes dysfunctional leading to an increase in chronic inflammatory distress signals and misfiring of hormonal and neurotransmitter messaging. As a consequence thereto, neuropeptides and hormonal signaling go haywire. For example, the aging hypothalamus changes neurohormone signals, which in turn affects food intake and metabolism. Since the hypothalamus also regulates sleep cycles, these changes can perturb sleep, inhibit DNA repair, accelerating aging even further.
Is chronic inflammation a common driver of many chronic diseases and accelerated aging ?
Difference betweent acute and systemic inflammation
Auto-immunity and pathogenesis
Analysis: Antibody tests, auto-immunity phenotypes and myriad infections, from Lyme disease to hepatitis, Epstein Barr, MRSA, Measels, HPV and more.
Earthing (grounding) and inflammatory diseases
Can holistic immunotherapy resolve most auto-immune, inflammatory and infection challenges ? Case Studies
Lesson 21: Cancer Hallmarks
“In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Cell. 2011 Mar 4;144(5):646-74 (Source)
As Research scientists better understand the underlying processes of carcinogenesis, Cancer Hallmarks are being fine-tuned. In this Lesson, we will review the classical cancer hallmarks, the emerging ones as well as the ACR Institute’s hallmarks.
Self-sufficiency in growth signals
Insensitivity to anti-growth signals
Limitless replicative potential
Tissue invasion and metastasis
Abnormal Metabolism, including its Immune system and microbiota
Genomic insta ility and chromosamal abnormalities
Degradation of the extracellular Matrix
Other complementary ACR Institute proposed Hallmarks
Lesson 22: Advanced Holistic Malignancy Control and Reversal Protocols
With the advent of the twenty-first century, two major misconceptions about cancer have eventually been eradicated: the notion that cancer is a purely cell-intrinsic disorder that stems from epigenetic or genetic alterations and (2) the view that malignant cells satisfy their bioenergetic and anabolic needs mostly (if not only) via aerobic glycolysis. Thus, it is now widely accepted that tumors form, develop and respond to therapy in the context of a complex, bidirectional interaction with the host immune system. It is in this perspective that the ACR Institute’s Holistic Immunotherapy protocol should be understood.
Summary of the HIP Protocol
Integrative Versus Conventional Oncology Models: Strengths and Limitations
Optimizing the Cancer Control, Repair & Reversal Code: a precondition to Optimal Longevity
Cancer Control and Reversal with Holistic Oncology: the ACR Institute’s HIP protocol
Case Study A: Modified Citrus Pectin, Inflammation and Cancer.
To see other topics that this section covers, please click here.
Lesson 23: Heat Medicine: A French & German Speciality that would be of Benefit for the US Health-Care system
“Give me the power to produce fever and I’ll cure all disease” Parmenides, 500 BC.
Belief in the curative power of feverish illnesses dates back to antiquity. Hippocrates spoke of the beneficial effect of fever on epilepsy and Galen cited the cure of a melancholic patient after an attack of quartan fever. During the 18th century, physicians began to send their patients to Fens to contract malaria to cure them of their insanity. However, it was not until the late 19th century that fever therapy began to gain widespread popularity and attract the support of distinguished physicians, including Maudsley and Esquirol. In the 20th century, different clinics were inoculating cancer patients with fever-causing bacteria that would produce effective immune responses against cancer, including Dr Coley from Harvard. And today, conventional oncology is finally understanding that immunotherapy is key.
What is heat medicine ?
French Thermal Medicine
German Hyperthermia Medicine
Over twelve disease conditions that can benefit from heat Medicine
Cancer and Fever
Heat Shock Proteins and Hormesis Mechanism
Hyperthermia and immunotherapy
Lesson 24: Optimizing balanced Hormones & Neuro-transmitters & Regulating Cytokines
“Scientists said they were struck by how suddenly and overwhelmingly the 1918 flu struck seven macaques that were tested (…) The virus spread faster than a normal flu bug and triggered a “storm” response in the animal’s immune systems. Their bodies’ defenses went haywire, not knowing when to stop, researchers said. The lungs became inflamed and filled with blood and other fluids. (…) “There was some surprise that it was that nasty,” University of Washington virologist and study co-author Michael Katze said. “It was the robustness of the immune system that helped victimize them.” (Source)
There are over fifty known hormones. Almost all affect personality and physiology. At least seven vary greatly with gender. With the gift of Life, we have been equipped with key messaging molecules, three are central: neurotransmitters, cytokines and hormones. With the passage of time, many of these molecules get roughed up and become imbalanced. This is why these messaging molecules need regular holistic and epigenetic “tune-ups”, especially then someone is trapped in the vicious cycle of accelerated aging. By holistic tune-ups, we don’t mean hormone or even bio-identical hormone replacement therapies.
The Hormone Chemistry & Longevity
Case Study A on DHEA, Pregenolone, Testosterone, Progesterone and Estrogen
Case Study B on Human Growth Hormone (HGH), IGF-1 Melatonin, Cortisol & Thyroxine
Case Study C on The Vasopressin & Oxytocin
The Oxytocin-Vasopressin Pathway in the Context of Love and Fear
Case Study: The Klotho Hormone as well as a few others
Case Study: Sweet Potatoes and Yams to Balance Hormones: the Evidence
Neuropeptides, Neuro-transmitters & Healthy Longevity
Defining Excitatory and inhibitory processes in Neuro-transmitters
Case Study on Serotoin, Dopamine, Acetylcholine, Norepinpehrine and GABA
Cytokines Signaling Molecules, Cytokines-Storms, Inflammaging & the Body’s integrity
The Role of endogenous cytokines in premature death, disease, health and longevity
Case Study A: Homeostatic Imbalance and Cytokine-storms
Case Study B: Holistic Interventions
Case Study C: Sepsis & Holistic Resolution
Case Study D: Influenza Pandemics
Lesson 25: Activating & Tweaking Key Longevity Genes
“Therefore I should infer from analogy that probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed.” (Darwin, Charles. On the Origin of Species. London: John Murray, Albermarle Street. 1859. pp. 484, 490).
In this Lesson, we will focus on activating three families of Longevity genes: the 7 members Sirtuin family, the APOE tribe and the wild FOXOs, a few members of whom can be helpful insofar as keeping human cellular repair and other longevity systems in decent shape. FOXO4 for example is elevated in senescent cells. (Source). Thus, to efficiently address senescent cells, we must also modulate this SNP (gene variation). Among other examples, let us consider one FOXO activator that is presently in the public debate.
What are Longevity Genes and what are their mechanisms of action ?
Cancer and Senescent Cells: An evolutionary marriage
SNPs, Methylation & other Pathways
FOXO3 Activators and Rejuvenation
Other Longevity Genes, the Continuum of Ancestral Genes & the universal nature of biochemistry
Lesson 26: Mitochondrial Bio-Genesis’ Restoration: From Cancer and Longevity to Fasting and Mitochondrial enhancers
“ ..aging can be modulated by genetic pathways and biochemical processes which are evolutionarily conserved” (Lopez‐Otin et al., 2013)
The capacity for mitochondrial biogenesis has been shown to decrease with age, and such decreased mitochondrial function has been associated with diabetes and cardiovascular disease. (Source) Aging and disease can induce changes in the expression levels of proteins involved in the fission and fusion mechanisms of mitochondria, thus creating dysfunctional mitochondria. (Source). One hypothesis for the detrimental results of aging is associated with the loss of telomeres, the end segments of chromosomes that protect genetic information from degradation (Source). Telomere loss has also been associated with decreased mitochondrial function. Mitochondria are a little like tiny power plants inside our cells. Couple of years ago, a team of researchers led by Newcastle University successfully showed how mitochondria are fundamental to the aging of cells. A new research from Harvard published in the journal Cell Metabolism showed how the changing shapes of mitochondrial networks can affect longevity and lifespan. More importantly the study illustrates how fasting manipulates those mitochondrial networks to keep them in a “youthful” state..
On the cancer front, contrary to conventional “wisdom”, functional mitochondria are essential for the cancer cell. Although mutations in mitochondrial genes are common in cancer cells, they do not inactivate mitochondrial energy metabolism but rather alter the mitochondrial bioenergetic and biosynthetic state. These states communicate with the nucleus through mitochondrial ‘retrograde signalling’ to modulate signal transduction pathways, transcriptional circuits and chromatin structure to meet the mitochondrial and nuclear requirements of the cancer cell. In this lesson, we will examine the underlying biological processes relative to mitochondrial biogenesis insofar as longevity and cancer are concerned.
Mitochondrial bio-genesis and its mechanisms of action
Fasting and other Holistic Techniques with regard to Mitochondrial renewal
Pyrroloquinoline quinone (PQQ) and Mitochondrial Biogenesis
Other Mitochondrial enhancers
Lesson 27: Stem Cells: Repair, Replacement & Regeneration
In adults, stem cells are responsible for the repair of damaged tissues, and the replacement and regeneration of tissues that turn over rapidly, such as the skin, blood or the lining of the intestine. Recent evidence suggests that most, if not all tissues may contain stem cells with the potential to repair damaged tissue”. (Source)
As humans become nutrient deficient and oxidize (lose electrons) with the accumulation of years on Earth, stem cells eventually lose their ability to divide and self-renew, notwithstanding their strong telomerase activity. As a result, they are unable to replace the stem cells that have migrated, differentiated, or died. Without enough stem cells, damaged cells can’t get repaired or replaced. Hence, the increase of age-related disorders. Because stem cell exhaustion is an important hallmark of aging, geroscientists and biogerontologists are working on attempts to rejuvenate stem cells with synthetic chemicals and high tech technology. However, most times, this leads to both drug resistance and significant complications and toxic effects. On the other hand, integrative and regenerative medicine focuses on the early “banking” (storage) of stem cells that can be inoculated to worn out tissues when needed. These integrative clinics are also starting to use autologous stem-cells via injections on the same visit day. Holistic medicine’s focus is on preserving and holistically replenishing stem cells for quality living over 100 years. (Source) Before dieing, supercentenarians tend to have fewer and fewer stem cells, less than a handful, it’s been recorded that one supercentenarian lady was living just on two stem cells. In this Presentation, we will therefore focus on holistic techniques to both preserve and produce quality stem cells that can repair and replace tissues in favor of a long healthy lifespan.
Stem cells and their mechanisms of action
Stem cells in relation to Longevity and Cancer
The Biotech Industry’s research on Stem Cells
Stem Cell injections and boosters
Can a Food and an Advanced Holistic Lifestyle replenish Stem Cells ?
Lesson 28: Telomerase Therapy
” Telomere length shortens with age. Progressive shortening of telomeres leads to senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health and lifespan of an individual. Shorter telomeres have been associated with increased incidence of diseases and poor survival. The rate of telomere shortening can be either increased or decreased by specific lifestyle factors”. Curr Opin Clin Nutr Metab Care. 2011 Jan; 14(1): 28–34.
Located at the end of our chromosomes, DNA repeats called Telomeres modulate the number of times cells divide. The longer the telomeres, the more cells divide, from 50 divisions or doublings to 70, which corresponds to about 120 years, which has been called the Hayflick limit.
Telomeres function like our bodies’ internal clocks, determining the rate at which we age. They shorten over time, as our cells divide, and when they become short enough, the chromosomes can no longer replicate and the cells that house them typically stop dividing and undergo senescence, or else die. This shortening is associated with a number of age-related conditions, such as diabetes, hypertension, Alzheimer’s disease, and cancer, as well as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis.
Telomere Biology and Mechanisms of Action
Telomere Shortening tends to accelerate Aging
Telomere Length characterizes Cancer
Telomerase Activators for Longevity
Holistic Interventions to strenghten and modulate telomerase
Top: Rosemary, one of the Mediterranean plants that is abundant in both the Mediterranean longevity valleys and in centenarians’ guts
Lesson 29: Cellular Senescence, Autophagy, Regulation & Amyloidosis
“In humans and other animals, cellular senescence has been observed to be connected to the shortening of telomeres with each cell cycle; when telomeres become too short, the cells die. The length of telomeres is therefore the “molecular clock”, Harvard Professor Hayflick.
When telomeres shorten, cells can’t divide anymore, at which point they become senescent. When we are vibrant, senescent cells are thought to be cleared by the immune and the autophagy systems, as a result, healthy lifespans tend to be much longer. On the other hand, when senescent cells stick around secreting harmful inflammation molecules and sticking to healthy cells, aging is accelerated. Canakinumab was manufactured to dampen this senescence inflammation called infammaging. But this drug has its limits. (Source). Unresolved DNA damage can impair cellular function, promote disease development, and accelerate aging. To prevent such undesired consequences, cells are equipped with a range of DNA repair mechanisms . However, these mechanisms are not flawless. When repair falls short, tissue integrity is still at least initially maintained by independent stress-response mechanisms as apoptosis and cellular senescence. In this perspective, senescent cells are permanently withdrawn from the cell cycle and generally develop a persistent pro-inflammatory phenotype, called the senescence-associated secretory phenotype (SASP). Unlike apoptotic cells, which are permanently eliminated, senescent cells can prevail for prolonged periods of time and accumulate with age. Because of their low but chronic SASP, persistent senescent cells are thought to accelerate aging and the onset of age-related diseases, including cancer.
When things are running smoothly in a cell, autophagy occurs at a low level, helping to recycle worn-out cellular components. It’s a type of ‘maintenance’ mode. But when things become stressed in a cell (not enough nutrients or energy, dysfunctional components, an accumulation of toxicants or invasion by microbes), autophagy kicks in its stress response mode. Activation of autophagy counteracts the age-associated accumulation of damaged cellular components and enhances the metabolic efficiency of cells. (Source) In particular, autophagy can be activated to remove dysfunctional mitochondria (mitophagy) which produce a lot of harmful reactive oxygen species (ROS) that degrade the cell (Source) These processes are reported to extend the lifespan of several species. (Source)
In this Lesson, we will examine a few holsitic techniques that can help to clear cellular senescent cells as well as activate autophagy and deactivate Amyloidosis.
Cellular senescence, autophagy and their mechanisms of action
Case Study A: A Review of different synolitics (senescent cell removers)
Case Study B: A review of different autophagy inducers and the link to longevity activation
Case Study C: Spermidine and Autophagy
Case Study D: Amyloidosis and the Art of Removing extracellular Deposition of Misfolding Proteins
Case Study E: The Transthyretin transport protein (TTR)
Lesson 30: Circadian Rythms Activation & DNA Repair
The aging hallmark relative to the circadian pathway is relatively new. The 2017 Nobel Prize in Physiology (Medicine) went to scientists who dug deep to unravel some of the mysteries of circadian biology. When humans don’t respect Nature’s rhythms like the sleep-wake (melatonin-cortisol) cycle, aging is accelerated.
Deep restorative Sleep is one of ACR Institute’s twelve most important wellbeing tools, more powerful than pills, surgery and any high-tech procedure combined, (in most cases) because none of conventional medicine’s weapons and procedures can repair damaged DNA, spur rejuvenation hormones, charge up neurotransmitters, calm inflammation, calm the mind and detox beat-up tissues like deep restorative sleep.
In this Lesson, we will examine the best deep sleep protocols, including, but not limited to different ways to holistically resolve Apnea, snoring, frequent urination and other sleeping problems. We will also focus on holistic ways to promote DNA repair.
Case Study A: Nicotinamide Adenine Dinucleotide, NMN & DNA Repair
NAD+ is a key co-enzyme and metabolite called Nicotinamide Adenine Dinucleotide (NAD+) that the mitochondria in every cell of our bodies depend on to fuel all basic functions. (Source) Over time, decreasing NAD+ promotes chronic diseases and aging. (Source). Different scientists claim that is one of the key factors that explains why we age (Source). In this NAD+ plays a key role in communicating between the nucleus of cells and the Mitochondria that power cell activity (Source). One of its key role is to ensure DNA repair, a longevity function which is essential.
Circadian Rhythms and Mechanisms of Action
DNA Repair and Mechanisms of Action
The metabolite NAD+ and DNA Repair
Pterostilbene and Resveratrol Combo
Other DNA and enzymatic endogenous repair systems
Lesson 31: Monitoring Tests: From Self-testing to Genetic, Gut, Telomere & Methylation Evaluation
In this Lesson, we will thus delved into some of the most important holistic, functional, integrative and allopathic tests that can be done to determine health and disease status, (diagnosis) to monitor disease progression (prognosis) and to evaluate the safety and efficiency of treatment plans and longevity protocols. We will also quickly look at dozens of biomarker lab tests that can detect underlying chronic conditions that are not yet symptomatic. Like with gut and genetic tests. We will also look at biological age testing, in particular telomere, epigenetic and methylation tests.
Which Monitoring tests are the best for longevity achievement and the reduction of chronic and degenerative diseases ?
Lesson 32: Today’s Bio-Engineering of anti-aging pharmaceuticals & Hi-Tech procedures
In this Lesson, we will look at some of the most interesting innovative technologies that are either freshly on the market or still being worked on, from biogerontology institutes in France, China, Japan, Germany, Israel to those in the US, including the Silicon Valley bio-tech giants and their prestigious scientists and billionaires. Some of these medical innovations target many of the aging mechanisms we have seen, from telomerase insufficiency, to senescent cell removal, (senolytics), caloric restriction mimickers, blood donor plasma transfer, nano-robots, gene editing, stem cell cyro-preservation, Sirtuin-activating molecules and the like. Pharmacological treatments have also been shown to extend lifespan through activation of autophagy, indicating autophagy could be equally a potential target to modulate animal and human lifespan. (Source)
We will therefore examine both the risks and benefits of what appears to be the most significant longevity procedures that mainstream science is investing in, including, but not limited to metformin, rapamycin, AMPK, quercetin, NAD+ and its maintenance molecule NR as well as blood plasma transfusion, gene therapy and more.
Analysis of a few of the pending Longevity Human Clinical Trials
Targeting Senescent Cells with Conventional Pharmaceuticals: successes and limitations
The Safety and Efficiency of High Tech Procedures like Blood Plasma Transfer (young blood to older blood)
Lesson 33. Conventional Cancer Research and Innovations
“Despite improvements in treatment, prostate cancer (PC) remains the second-leading cause of cancer death in men. Radiotherapy is among the first-line treatments for PC, but a significant number of patients relapse. Recent evidence supports the idea that PC is initiated by a subset of cells, termed cancer stem cells (CSCs). CSCs have also been implicated in radioresistance in various malignancies,. (…) These data suggest that, although CSCs are initially damaged by radiation, they possess a greater capacity for recovery and regrowth”. (Source)
By killing healthy cells like the immune and stomach lining cells with Pharma’s weapons of mass cellular destruction, the body doesn’t have much of a chance to restore homeostasis and those T killer cells whose evolutionary job is to get rid of viruses, bacteria and cancer cells. By killing fast growing tumor cells, chemo and radiotherapy reinforce the slow-growing cancer stem cells whose genome makes it stronger, thanks to which these cells are then able to metastasize to full victory. Cancer stem cells are by nature metastatic and both radiation and chemo spur these cells to get angry and then stronger. The evidence has been established for over fifteen years. In an article titled, “Radiation Treatment Generates Therapy Resistant Cancer Stem Cells From Aggressive Breast Cancer Cells,” published in the journal Cancer July 1st, 2012, researchers from the Department of Radiation Oncology at the UCLA Jonsson Comprehensive Cancer Center reported that radiation treatment drives breast cancer cells into greater malignancy, by over 30 times. Radiotherapy does this by increasing the ratio of highly malignant to benign cells within that tumor. (Source).
On the other hand, there are some promising conventional cancer research projects and clinical trials that target the immune system. In this Lesson we will look at the different innovations with the CAR-T therapy, monoclonal antibodies, check-point inhibiters and multiple targeted and combinational therapies.
Lesson 34: Summary & Conclusion
Honing in on Key Rejuvenation and Life Extension Techniques
The Optimal Longevity Tune-up Protocol in a Nutshell
The Healing Milieu & the Entourage Effect
The Holistic Therapeutic Effect Principle
For the O.L Master Class’ Closing Remarks (from the Institute’s Book), click here. Reserved for the Registered Viewers
Video Excerpt on a 2016 Optimal Longevity Medicine Lecture from Pr. Joubert
“The art of medicine consists in amusing the patient while Nature cures the disease.” Voltaire. One of 18th century Voltaire’s lessons to heal and be happy is to “cultivate one’s garden” (cf in his book Condide), that which can be translated to mean the cultivation of the low-key attitude of being joyfully humble and humbly joyful with an uplifting sense of purpose, awe and gratitude holistically expressed in the “now and here”, what is called “la joie de vivre”.
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