“It is already possible to live to be well over 120 years (…) In my own laboratory at UCLA Medical Center, we have extended the maximum life span of fish by 300 percent.” Maximum Life Span”, NY: W. W. Norton, 1983 by Roy L. Walford, M.D.
- 1 The Originality of this Training
- 2 Lesson 1: The Magic of Meditation: From Genomic Expression to Joie de Vivre (JDV) Consciousness Activation
- 3 Lesson 2: The Basics of Biogerontology
- 4 Lesson 3. The Biology of Aging: Understanding the Mechanisms that Spur Accelerated & Delayed Aging
- 5 Lesson 4: The Hallmarks of Aging
- 6 Lesson 5: Holistic Cardiology in a Nutshell.
- 7 Lesson 6: Detoxification, Fasting & Cleansing for Optimal Longevity
- 8 Lesson 7: Quality, Traditional & Moderate Wine intake extends Healthy Lifespans
- 9 Lesson 8:The Endocannabinoid System, Homeostasis & Longevity
The Originality of this Training
This Master class addresses cancer & other chronic diseases from the longevity and bio-terrain angle with the best available Science and healing practices we know of. By addressing the tumor (s) microenvironment as well as the person’s bioterrain holistically and with Optimal Longevity medicine, the body will more often than not resolve the cancer as well as many of the other degenerative challenges the patient may be suffering from. Furthermore, as a bonus for activating the longevity pathways, the Master Class attendee enriches his or her bioterrain with what is needed to live a long healthy lifespan of 120 years old.
The following evidence-based 32 Lessons are based on the latest research in cancer-free longevity science. Each Lesson lasts around two hours. Topic Analysis, Clinical Pearls, Holistic Tips and a Q & A session follow each Lesson. At the end of the training, a certificiation exam will finalize this Master Class.
Each Lesson will be preceded with a longevity enhancement type of Meditation exercise
Lesson 1: The Magic of Meditation: From Genomic Expression to Joie de Vivre (JDV) Consciousness Activation
“I regard consciousness as fundamental. I regard matter as derivative from consciousness” Max Planck (leading expert in quantic physics, Nobel laureate)
Researchers at the University of California were the first to show that meditators have significantly higher telomerase activity than non-meditators. (Source) Furthermore, the regular practice of specific types of Meditations we teach all Workshop attendees will simultaneously signal longevity genes to activate telomerase enzyme gene and many other biological processes to sharpen both intuition and focus. As a bonus, intellectual assimilation of the content of this Certification program will be enhanced. We will therefore begin and end each 2 hours training Lesson with short guided Meditation practices.
We will prove all of the Institute’s claims with a preponderance of the hard evidence during the power point presentations.
Introduction to Cancer-free Holistic Rejuvenation Medicine
“The field of ageing research has been completely transformed in the past decade. . . . When single genes are changed, animals that should be old stay young. In humans, these mutants would be analogous to a ninety year old who looks and feels forty-five. On this basis we begin to think of ageing as a disease that can be cured, or at least postponed. . . . The field of ageing is beginning to explode, because so many are so excited about the prospect of searching for – and finding – the causes of ageing, and maybe even the fountain of youth itself”. (Guarente and Kenyon, Nature, 2000)
For millennia, the aging process has been considered to be uncontrollable, even when the average lifespan did not surpass 40 years, which was just a little over 100 years ago. That changed with Professor Elizabeth Blackburn’s discovery of the telomerase gene. (Source) Furthermore, in the early nineties, research on C. elegans, (a tiny nematode worm) confirmed that a single gene mutation extended its life, and that another mutation blocked that extension. (Source)
The idea that age could be tweaked by twiddling a few control genetic switches ignited a research and investment boom. As more geroscientists and biogerontologists got better motivated to attempt to break and hack the Longevity Code, new findings started to reveal key biological clocks that epigenically switched on and off longevity genes. (See Exhibit C)
In this perspective, various clinical interventions did increase the worm’s lifespan by a factor of ten and those of lab mice by a factor of two. (Source) Thereafter, telomeres of skin cells were tweaked to lengthen the new unprecedented levels, thanks to a new Lab procedure fine-tuned by Stanford university School of Medicine scientists. These cells were able to divide up to 40 more times more than untreated cells, which means that human somatic cells have been empirically shown to surpass the Hayflick limit and potentially extend their lifespan 40 times more than before. “Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells”. (Source)
This means that we now have some limited evidence that we may have in us the regenerative potential to live 40 times more than the Hayflick limit. The Havflick limit is in between 50 to 70 cellular divisions, before the cell either dies or transitions into a senescent cell. Seventy divisions is roughly 120 years. 40 times 120 = 4800 years.
The scientific consensus that human lifespan potential was a little after 100 years old thus transformed. The perception of the Aging process went from a few decades of endless struggling to survive to a Darwinian reproduction of the human species (Cf Time cover from 1958: “Growing Old Usefully”), followed by a social issue (Time, 1970: “Growing Old in America: The Unwanted Generation”) to this “je ne sais quoi” phenomenon (1996: “Forever Young”) that could defer death to 142 years for starts (Cf 2015: Time “This Baby Could Live to Be 142 Years Old”).
However, because in Life, there are many howevers, the excitement was not long lasting. Successfully tweaking genes in a Petri dish does not necessarily translate into in vivo genetic expressions of supercentenarian lifespan. It was soon discovered that the telomerase enzyme gene was not the central longevity engine anti-aging experts had hoped for. The Longevity Code cook-book is far more complex for mammals and even more so for humans than for a C. Elegans worm, fly, mouse, naked mole or even the bat (who has an exceptionally long lifespan).
Hence, the Institute’s director, Pr. Joubert, prefers to focus on the known fundamentals that work to at least 122 years of age while simultaneously exploring the best of bio-tech longevity engineering stratagems, many of which are still in the early phases of clinical trials and concomitant marketing schemes.
As we will see, there are many dozens of ongoing drugs and supplements that are already being used in today’s anti-aging and baby-boomer communities, from telomerase activators and senescent cell removal, (senolytics) to autophagy inducers, caloric restriction mimickers, blood donor plasma transfer, nano-robots, mTOR drugs like rapamycin, gene editing, stem cell cyro-preservation, NAD enhancers, sirtuin-activating molecules, insulin-modulating drugs like metformin and more.
Most of these molecules and products are still under investigation in different clinical trials. Many have not even been tested in terms of drug-supplement-food interactions. Not only it can take many years for many of these anti-aging human trials to be completed, but once on the market, many of these anti-aging products will be too expensive for the general public and many of these products are not immune from deleterious side effects. As a consequence, risks may outweigh benefits, especially for people who are relatively healthy and are just seeking to add 30 or 40 extra healthy years to their lifespan.
Thus, waiting a few years before some of these bio-tech longevity hacks may be accessible and proven safe and effective is not cellularly or financially responsible, if only because today we have the knowledge that key holistic tools can significantly help to rejuvenate, repair and restore most metabolically impaired tissues to way over 100 years. Furthermore, Holistic and Happiness medicine can also meaningfully help to offset and significantly delay Evolution’s programmed aging process. In effect, by addressing cancer cells holistically with the ACR Institute’s discoveries and techniques, we can also clear senescent, ectopic endometrial and other degenerative cells and debris that hinder healthy supercentenarian lifespans.
Lesson 2: The Basics of Biogerontology
“The idea is to die young as late as possible.” (Ashley Montagu).
Biogerontology: principles and key Findings
Distinction between Accelerated and Delayed Aging
The ACR and O.L. Institutes’ central Premise on Aging and Longevity
Nobel Professors of Physiology whose recent findings have meaningfully enhanced the value of Rejuvenation Medicine
Biomarkers (Aging and Longevity)
The Epigenetic Clock
Case studies of a few Humans and Animals who have significantly outlived their peers
Top: The French Mediterranean dancer, Madame Jeanne Calment, a Piscean born on February 21, 1875, is still the Optimal Longevity Champion, notwithstanding some evidentiary controversies. Having reached 122.5 years, according to her claims, she “allowed” herself to die. In other words, she could have continued to live. Her age was confirmed via birth certificate and the Guiness Record scientist-investigators, in conjunction with university experts, confirmed this fact as well as many other facts that proved beyond any reasonable doubt that human beings were capable of reaching 122 years of Life without major chronic diseases and without any drugs or supplements. In this picture, she was 120.
Lesson 3. The Biology of Aging: Understanding the Mechanisms that Spur Accelerated & Delayed Aging
“Medicine is not only a science; it is also an art. It does not consist of compounding pills and plasters; it deals with the very processes of life, which must be understood before they may be guided.” Paracelsus
What is Biological Aging & Senescence ?
Different Theories of Biological Aging
Cancer cells & Supercentenarians: Common threads
Top: A young infant girl who suffers from Proregia syndrome. She is only around 2 years old, but appears much more. Also known as Hutchinson-Gilford syndrome, this disease is genetic. It is characterized by accelerated aging that is accompanied with the age-related diseases. The mean age at death of these patients is 12.5 years. These children die “old” before 15 or 20, at which point they look like 80 years old.
Case study A: Ultra rapid metabolic accelerating-aging
Top: A 16 years old little girl who stopped growing at 11 months.
Case Study B: Ultra-slow Growth: Children who do not Age, genetically “frozen” in Time
Roundworms Experimentations confirm: aging and lifespan is regulated in part through the insulin/IGF-1 and mTOR pathways.
Top: the transparent nematodeC. elegans.This roundworm is one of the most studied for neurodegeneration and longevity. Scientists have been able to significantly extend its lifespans by tweaking its genes.
The IGF-1 & mTOR pathways
In Search for a Working Hypothesis of the Key mechanism(s) of Aging
The Major Molecular Mechanisms that best Explain the Aging Process
What are the genetic variants or determinants that account for extreme longevity in humans ? Do these variants prevail over Lifestyle and the environment ?
“Centenarians are the best example of extreme human longevity, and they represent a selected population in which the appearance of major age-related diseases, such as cancer, and cardiovascular diseases among others, has been consistently delayed or escaped. The study of the long-lived individual genetic profile has the purpose to possibly identify the genes and the allelic variations influencing extended life expectancy, hence considering them as biomarkers of age-related diseases onset and development. The present study shows no significant differences between allelic variations of ABO blood groups among a group of centenarians from Western Sicily”.
Lesson 4: The Hallmarks of Aging
1. Genomic instability.
2. Mitochondrial DNA Break-down & Dysfunction
3. Telomere Shortening and Telomerase Depletion
4. Epigenetic Alterations
5. Loss of Proteostasis
6. Deregulated Nutrient-sensing
7. Cellular Senescence
8. Stem Cell Exhaustion
9. Altered Intercellular Communication.
Summary on the First Nine Hallmarks
Complementary Hallmarks identified by the ACR & OL Institutes
Longevity Mechanisms in supercentenarian & long-lived animals
Top: The naked mole rat who also broke the world record for longevity in its category. This fleshy rat is one of the ACR and OL Institute’s Heros as the NM Rat has demonstrated successful Longevity pathways that are relevant to the OL Institute’s Optimal Longevity Model.
Negligible senescence in the longest living rodents, the naked mole-rats & their DNA repair system
Gompertz Aging law and Biological “Immortality”
Tentative Concluding Remarks on Senescence and Aging mechanisms
The Workshop’s Guiding Hypothesis on a unified theory of aging
Top: coronary heart disease can be visually detected with a simple ear examination anyone can do
Lesson 5: Holistic Cardiology in a Nutshell.
“Keep a quiet heart, Sit like a tortoise, Walk sprightly like a pigeon, Sleep like a dog” (Longevity advise from Li Ching-Yuen. Li was a mountain herbalist & a wine enthusiast who seemingly lived to 197 years).
Healthy extended lifespans need healthy epithelium. If the lining of the vessel walls are not healthy, all of the other tissues are affected. Blood flow is key and both holistic and nutritional medicine focus on this priority by prescribing daily servings of nitric oxide promoting dark green veggies. (Source) When the epitehlium is damaged, Cardiovascular diseases (CVD) abound. CVDs in the US constitute both the First cause of premature death and the easiest epidemic to fixed holistically. If holistic and happiness medicine were the standards of care, conventional cardiology would go bankrupt within days, thanks to which millions of Americans would avoid CVDs and get closer to acheive their 120 years potential.
In this Lesson, we will examine the hard evidence that shows that most of conventional cardiology is both outdated and laden with deleterious consequences that hinder the People’s birthright to live a healthy lifespan to 120 years. Concomitantly, we will prove via published power point studies that integrative and holistic cardiology are clinically safer, more effective and cost-friendlier.
Extended Lifespans need Strong Hearts, Smooth Vasculature & a balanced angiogenesis process
Erectile Dysfunction (E.D.) is a “CVD canary in the Coal Mine” symptom that justifies an immediate rendez-vous with Cardiology Monitoring
Debunking myths & misleading claims regarding Fats
To Salt or Not to Salt ? The Evidence on Salt and CVD Diseases
Case Studies: Reversing Cardio-vascular diseases (CVDs) with Holistic Cardiology
Lesson 6: Detoxification, Fasting & Cleansing for Optimal Longevity
“There were never so many able, active minds at work on the problems of disease as now, and all their discoveries are tending toward the simple truth that you can’t improve on nature.” (Thomas Edison, 1902)
In Conventional medicine, the Government’s N.I.H experts claim that “…there isn’t any convincing evidence that detox or cleansing programs actually remove toxins from your body or improve your health. Weight loss on a detox diet may be because these diets are often very low in calories” (Source) while independent but conventional scientists in peer-reviewed studies will outrightly debunk detoxification techniques as being useful for disease reversal and longevity. On the other hand, experts in the integrative-functional-holistic fields validate detoxification’s powerful impact on healing. After assessing the pros and cons of holistic and metabolic detoxification, the Happiness Medicine Institute has determined that detoxification in general is overwhelmingly supported by the evidence and constitutes a powerful rejuvenation technique, notwithstand a few isolated and unsupported cash-flow motivated claims in the alternative health field.
In this Lesson, we will thus compare the arguments and facts with regard to the pros and the cons of different detox techniques and then make a reasonable determination as to where the preponderance of the evidence lies regarding some of the more popular detoxificataion claims that are invoked in the integrative and holistic fields: in particular: anemas, colonics, saunas, ionic foot baths, detox supplements (clays, ALA, Nac, milk thistle etc), diet, fasting, sweating, exercises and more.
Sauna, Hydrotherapy & Hot tub Therapies
Removing Glyphosate & other deleterious chemicals
Detoxing from heavy metals, molds and damaging parasites (most molds & parasites thrive on heavy metals)
Home Detox from the Sick Building Syndrome
Occupants of water-damaged buildings (WDBs)
Fasting Techniques for Detoxification
On the New “fasting mimicking diet” trend being adopted by the Anti-Aging Community
Chelators and Binders
What is the best Diet, the best nutrients, the best lifestyle and the best supplements for safe and efficient detoxification
What is the best “detox” water to Drink ? (Hydration & Types of Water)
The Myth of Drinking Lots of Water
Some “Toxicant & Cellular garbage disposal” help from our Microbiota Gluthatione-producing Friends
Case Studies A : Titanium Dioxide Nanoparticles & Other examples
Case Studies B: Arsenic, Mercury, Cadmium, DDT, Lead, Candles and More
Lesson 7: Quality, Traditional & Moderate Wine intake extends Healthy Lifespans
“Stop drinking only water, and use a little wine because of your stomach and your frequent illnesses.” 1 Timothy 5:23
The evidence the Presentation will share suggests that early death and multiple chronic diseases appear to be either partially or primarily the result of abstaining from this “essential nutrient” we call wine. But only if the dosage is “small to moderate”.
As Paracelsus said over two thousands years ago, “wine is a medicine, a food or a poison depending on the dosage”, to which we can add quality, pairing and timing. Too much wine will obviously harm the liver, the brain and other organs, but in the right proportion and context, wine can be a good medicine, just like essential oils, sunlight, exercises, heat, botanicals, caloric restriction, food, sound and the like. But for wine to be great medicine, it must be sipped holistically and its grapes and vinification should be prepared traditionally, (for that extra resveratrol boost) and without chemicals. Today, in the United States, the FDA allows Americans to drink wine that can have up to 76 additives, including but not limited to arsenic, lead and glyphosate. (Source) And because the US government does not require labeling, the wine consumer should ascertain that the wine is organic and traditionally made.
In this Lesson, we will examine a few diseases that quality wine can help to both control and reverse as well as its impact on longevity.
“Wine is a traditional beverage that has been associated with both healthy and harmful effects. Conceptions like the so-called “French paradox” or the beneficial impact of the Mediterranean diet suggest benefit. (…) there is reasonable unanimity in beneficial effects of moderate wine consumption in cardiovascular disease, diabetes, osteoporosis, maybe neurological diseases, and longevity”. (Source)
On the issue of “Moderate” and “biologically indicated” quality wine
Does One glass of Red Wine a day contain enough Live Chemistry for Longevity Benefits ?
Why most pub-med published articles on wines are flawed
Analyses of over twelve disease conditions quality & properly dosed wine can safely and efficiently address
Can wine activate the longevity pathways ?
Lesson 8:The Endocannabinoid System, Homeostasis & Longevity
“It’s not because we are old that we don’t play, it’s because we don’t play that we get old” (George Bernard Shaw)
“It’s not because we are old that we don’t play, it’s because we don’t play that we get old” (George Bernard Shaw)
The endocannabinoid system (ECS) is a newly discovered biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system. The endocannabinoid system is also involved in regulating a variety of physiological and cognitive processes including but not limited to general homeostasis and brain rejuvenation (neurogenesis). Likewise with cancer and over one hundred heath disorders.
“…cannabinoids may inhibit tumor growth by causing cell death, blocking cell growth, and blocking the development of blood vessels needed by tumors to grow. Laboratory and animal studies have shown that cannabinoids may be able to kill cancer cells while protecting normal cells”. (From the Federal Government’s National Cancer Institute) Source
In this Lesson , after a brief review of the endocannabinoid system (ECS) and one of its diseases officially called clinical cannabinoid deficiency disorder (CECD), we will look at a recent finding regarding cannabiniods’ role in optimal longevity. In this perspective researchers in 2017 confirmed that cannabinoids may be a forgotten essential nutrient, in particular for the elderly. Because levels of natural cannabinoids in the ECS decline with aging, these researchers focused on the correlation between cannabinoids and memory and provided convincing evidence that the lack of cannabinoids is a proximate cause of the loss of memory function in later life. Medical marijuana has also been shown to be beneficial for the elderly regarding pain management. (Source) We will also show that it is possible to stave off cognitive decline by using low doses of tetrahydrocannabinol to supplement endogenous cannabinoids. Likewise with Cannabis’ benefit effect with mitigating the United State’s hard alcohol and prescription opiate epidemics. Cannabinoids from different plants will also be reviewed in terms of their contribution to healthy lifespans, including, but not limited to different varieties of exotic peppers that also contain healing cannabinoids.
Is the Body’s Endocannabinoid System essential insofar as general homeostasis, wellbeing & Longevity are concerned ?
Analyses on Cannabis as medicine for over 12 disease conditions
The Big Three C’s: Cannabinoids, Curcuminoids and Carotenoids
Case study: Cannabinoids and Cancer
Case Study: Cannabinoids and Longevity pathways
To Continue the Training with additional Lessons, click here
Video Excerpt on a 2016 Optimal Longevity Medicine Lecture from Pr. Joubert
“The art of medicine consists in amusing the patient while Nature cures the disease.” Voltaire. One of 18th century Voltaire’s lessons to heal and be happy is to “cultivate one’s garden” (cf in his book Condide), that which can be translated to mean the cultivation of the low-key attitude of being joyfully humble and humbly joyful with an uplifting sense of purpose, awe and gratitude holistically expressed in the “now and here”, what is called “la joie de vivre”.
Page under Construction
DISCLAIMER. Nothing in this blog-website should be construed as medical or legal advise, including, but not limited to replies, comments and posts, all of which should not be deemed to constitute either a therapist-patient nor an attorney-client relationship. For all and any serious disease, the Institute recommends consulting with a competent Health-care practitioner who has both conventional and holistic medical training and clinical experience.
2019 (c). Advanced Cancer Research Institute and agents. All rights reserved